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Pomegranate Peel Extract CAS 476-66-4 Ellagic Acid
Ellagic Acid
Botanical Source: Punica granatum L.
CAS NO.: 476-66-4
Plant Part Used: Hull / Skin
Specification: Ellagic acid 40%-95% HPLC
Appearance: Fine brown yellow to gray white powder.
Features:
Pomegranate belongs to Punicaceae, and it is sheepberry or small arbor. It originates from Iran and Afghanistan and now is widely cultivated in China. Based on the local situtation of geographical position and climatic conditions, pomegranate have characteristics like high productive capacity and adequate quality. Thus, the steady supply of raw materials, high yield can be guaranteed.
Main Function:
- Resist to anti-oxidance, senescence inhibition and skin whitening;
- Restrain to human immunodeficiency virus(HIV) and many kinds of microbe and virus;
- Anti-oxidant, coagulant, descenting blood pressure and sedation;
- Treat kinds of symptoms caused by high blood sugar, hypertension;
- Resist to atherosclerosis and tumour;
- Anti-cancer & anti-mutation. Pomergranate extract has been proved to be an effective anti-carcinogen upon carcinoma of rectum and colon, esophageal carcinoma, liver cancer, lung cancer, carcinoma of tongue and skin.
Specification
| Items | Standards | Results |
| Physical Analysis | ||
| Appearance | Fine Powder | Conforms |
| Color | Yellow needle-like crystals | Conforms |
| Odor | Characteristic | Conforms |
| Mesh Size | 100% through 80% mesh size | Conforms |
| General Analysis | ||
| Identification | Identical to R.S. sample | Conforms |
| Ellagic Acid | ≥90% | 90.9% |
| Extract Solvents | Water and Ethanol | Conforms |
| Loss on Drying (g/100g) | ≤5.0 | 3.24% |
| Ash(g/100g) | ≤5.0 | 2.05% |
| Chemical Analysis | ||
| Pesticides Residue (mg/kg) | 0.05 | Conforms |
| Residual Solvent | <0.05% | Conforms |
| Residual Radiation | Negative | Conforms |
| Microbiological Analysis | ||
| Total Plate Count(cfu/g) | ≤1,000 | 300 |
| Molds and Yeast (cfu/g) | ≤100 | 29 |
| Coliforms (cfu/g) | Negative | Conforms |
| Salmonella(/25g) | Negative | Conforms |
Function
1. Scavenging free radicals
Since the 1950s, the antioxidant properties of ellagic acid in the human body and in vitro have been continuously explored and studied, and more and more research results have shown that ellagic acid has strong free radical scavenging and antioxidant capabilities. Ellagic acid has a scavenging effect on oxygen free radicals and hydroxyl free radicals, and its ability to scavenge free radicals is higher than that of antioxidants such as sesamol, olive leaf extract and lutein.
2. Inhibit lipid peroxidation
In inhibiting lipid peroxidation, ellagic acid is considered to be the most effective inhibitor of the initial stage of microsomal NADPH-dependent lipid peroxidation. Ellagic acid can also strongly inhibit the lipid peroxidation induced by adriamycin. . Ellagic acid inhibits iron myoglobin/hydrogen peroxide-dependent lipid peroxidation. Ellagic acid can prevent lipid peroxides (LPO) caused by exogenous substances in T cells, inhibit the production of reactive oxygen species (ROS), and improve cell death caused by cytotoxins.
3. Other antioxidant activities
Ellagic acid can reduce the cell damage caused by radiation, hydrogen peroxide and mitomycin C in mouse bone marrow cells. Ellagic acid effectively inhibits the oxidation of DCDHF induced by peroxynitrite and the oxidation of peroxynitrite itself. At the same time, ellagic acid prevents the single-strand break of pTZ 18U plasmid DNA induced by peroxynitrite and the nitration of tyrosyl groups in calf serum albumin. Therefore, in vitro, ellagic acid protects biomolecules from oxidative and nitrifying damage caused by peroxynitrite.
4.The activation of pancreatic astrocytes is an important cause of pancreatic fibrosis, acute pancreatitis and other diseases. Ellagic acid inhibits the activity of activin-1 and mitogen-activated protein kinase induced by interleukin 1b (IL-1) and tumor necrosis factor-α (TNF-α), thereby inhibiting the transformation of new pancreatic astrocytes It is an activated fibrous phenotype. As a secondary metabolite, ellagic acid plays a role in anti-eosinophilic activity in the β-glucan peritonitis model. Ellagic acid is an effective inhibitor of eosinophils and can be used to treat allergic inflammation. Ellagic acid can resist carbon tetrachloride-induced liver poisoning in vivo and in vitro, and it can also resist lipid peroxidation induced by tert-butyl hydroperoxide, so it has the effect of protecting the liver.
5.Melanocytes exist in the basal layer of the epidermis, where melanin is produced. The raw material for melanin production is tyrosine (tyrosine), and tyrosine must be converted into dopa (DOPA) and dopaquinine (DOPAquinine) by tyrosinase, and finally melanin (melanin) is formed. Ellagic acid blocks the production of melanin by inhibiting the activity of tyrosinase.Therefore, high-purity ellagic acid is mainly used as an additive in medicines, health foods and cosmetics, as functional factors such as anti-oxidation, suppression of human immunodeficiency virus, and skin whitening.
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